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Nasal Drug Delivery System: A Review

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Nasal Drug Delivery System: A Review


Aarti C. Nangare | Sujit Kakade | Ashok Bhosale



Aarti C. Nangare | Sujit Kakade | Ashok Bhosale "Nasal Drug Delivery System: A Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-5, August 2021, pp.572-579, URL: https://www.ijtsrd.com/papers/ijtsrd43868.pdf

The use of the nasal route for the delivery of challenging drugs such as small polar molecules, vaccines, hormones, peptides and proteins has created much interest in nowadays. Due to the high permeability, high vasculature, low enzymatic environment of nasal cavity and avoidance of hepatic first pass metabolism are well suitable for Systemic delivery of drug molecule via nose Many drug delivery devices for nasal application of liquid, semisolid and solid formulation are investigated to deliver the drugs to the treat most crisis CNS diseases (i.e., Parkinson’s dis-ease, Alzheimer’s disease) because it requires rapid and/or specific targeting of drugs to the brain. It is well suitable for the delivery of biotechnological products like proteins, peptides, hormones, DNA plasmids for DNA vaccines to give enhanced bioavailability. This review sets out to discuss some factors affecting nasal absorption, bioavailability barriers, strategies to improve nasal absorption, new developments in nasal dosage form design and applications of nasal drug delivery system.

Bioavailability, Patient Compliance, First pass effect, absorption Enhancers


IJTSRD43868
Volume-5 | Issue-5, August 2021
572-579
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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