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Transgenic Animals: A Better Approach towards Experimentation

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Volume-5 | Issue-2

Last date : 24-Feb-2021

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Transgenic Animals: A Better Approach towards Experimentation


Swarnima Negi | Dr. Sachdev Yadav



Swarnima Negi | Dr. Sachdev Yadav "Transgenic Animals: A Better Approach towards Experimentation" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2, February 2021, pp.13-17, URL: https://www.ijtsrd.com/papers/ijtsrd38268.pdf

Animals play a crucial role in the development of medical products from medicines to various implants and major surgical procedures. They are not approved for human use until they qualify the safety parameters in animals. The animals play a pivotal role in drug discovery and development. One of the most challenging aspects of targeting drugs for any pathological condition is the development of animal models. Animal models are nothing but an approach to replicate the general symptoms of the diseased condition which occur in humans. The whole pathophysiology cannot be replicated but, the symptoms which are known and precipitate the most in any pathological condition are positively reproduced within the animal. With the increasing need in the medical field, the paradigm is now slowly shifting towards transgenic animals as they have given a new dimension to medical sciences to study the pathophysiology of the disease rather than focusing on the symptom-based analysis of the diseased condition. These genetically modified organisms have shown groundbreaking results not only in developing models for various diseases but also in developing biopharmaceuticals, receptor-selective drugs, and have a huge contribution to xenotransplantation and the agriculture sector. This review article vividly describes the newer approaches that are adopted to develop transgenic animal models and also highlights certain limitations to the older approach of developing the models.

Transgenic animals, in vivo models, ex vivo models, transgenesis, xenotransplantation, disease resistant animals


IJTSRD38268
Volume-5 | Issue-2, February 2021
13-17
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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