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Reverse Aging by Punica granatum L. Peel Extract on Rat Model

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Reverse Aging by Punica granatum L. Peel Extract on Rat Model


Akanksha Samuel | Yogita Dobhal

https://doi.org/10.31142/ijtsrd12999



Akanksha Samuel | Yogita Dobhal "Reverse Aging by Punica granatum L. Peel Extract on Rat Model" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-4, June 2018, pp.640-647, URL: https://www.ijtsrd.com/papers/ijtsrd12999.pdf

While connecting the dots to all the possibly known diseases, it lead us to a single root cause, an increased level of free-radicals. Apart from the external sources, internally sources as well, trigger the natural-aging-clock i.e. the length of the telomere. The present study was focused on the chemical constituents being, polyphenolic tannins (ellagic acid, punicallin, punicalagin) being converted into urolithins. Ageing was induced by oral administration of soft-drink for 6 weeks in positive control group resulted increase in body weight, lipid-peroxidase & low-density lipids. The oral administration dose of pomegranate aqueous peel extract in group T1(a) 50mg/kg & group T1(b) 10 mg/kg of body weight & pomegranate fruit juice in group T2(a) 2ml/kg & T2(b) 3 ml/kg of body weight, was given for 3 weeks. Furthermore, the combination of both aqueous peel extract & fruit juice in group T3 was 100mg/kg & 3ml/kg of body weight administered orally. The pomegranate aqueous peel extract shown to be a potent antioxidant than the pomegranate fruit juice. Whereas, among all the treatment groups, group T3 shown significant increase in superoxidases, reduced glutathione, free radical scavenging activity, high-density lipids & memory retention as compared to the positive control group.

free radicals, telomere, antioxidant, ORAC, Punica granatum L., ellagic acid, punicallin, punicallagin, polyphenol, polyphenolic tannins, urolithins, anti-aging


IJTSRD12999
Volume-2 | Issue-4, June 2018
640-647
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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