The development of effective wound healing strategies remains a critical area of research, particularly in the face of increasing antibiotic resistance. This study focuses on the formulation and evaluation of a double-crosslinked hydrogel incorporating azlocillin-loaded silver nanoparticles for enhanced antibiotic activity and improved wound healing. Azlocillin, a broad-spectrum ß-lactam antibiotic, was combined with silver nanoparticles (AgNPs) to create a hydrogel that provides both sustained antimicrobial effects and promotes tissue regeneration. The hydrogel formulations were prepared using a combination of polyvinyl alcohol (PVA), sodium alginate, and chitosan, crosslinked both physically and chemically. The hydrogels were evaluated for their physical appearance, mechanical properties, pH, drug release profile, antimicrobial activity, and biocompatibility. The results indicated that the PVA-Alginate composite hydrogel exhibited superior performance in terms of drug release, antimicrobial efficacy, and stability over time. The hydrogel formulations demonstrated controlled and sustained release of azlocillin, providing prolonged protection against wound infections. Furthermore, the incorporation of silver nanoparticles enhanced the antimicrobial activity, particularly against common wound pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa. These findings suggest that the developed hydrogel systems have the potential to be an effective and innovative approach for treating chronic wounds and preventing infections in wound healing applications.
Double-crosslinked hydrogel, azlocillin, silver nanoparticles, wound healing, drug delivery, antimicrobial activity, polyvinyl alcohol, sodium alginate, chitosan, infection control
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