Home > Pharmacy > Pharmaceutics > Volume-9 > Issue-4 > Formulation and Evaluation of Double-Crossed Linked Hydrogel using Azlocilin-Silver Nanoparticles for Better Antibiotic Effect or Wound Healing

Formulation and Evaluation of Double-Crossed Linked Hydrogel using Azlocilin-Silver Nanoparticles for Better Antibiotic Effect or Wound Healing

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Volume-9 | Issue-4

Last date : 27-Aug-2025

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Formulation and Evaluation of Double-Crossed Linked Hydrogel using Azlocilin-Silver Nanoparticles for Better Antibiotic Effect or Wound Healing


Babli | Hakim Singh Rajput | Amresh Gupta



Babli | Hakim Singh Rajput | Amresh Gupta "Formulation and Evaluation of Double-Crossed Linked Hydrogel using Azlocilin-Silver Nanoparticles for Better Antibiotic Effect or Wound Healing" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-9 | Issue-4, August 2025, pp.30-34, URL: https://www.ijtsrd.com/papers/ijtsrd97189.pdf

The development of effective wound healing strategies remains a critical area of research, particularly in the face of increasing antibiotic resistance. This study focuses on the formulation and evaluation of a double-crosslinked hydrogel incorporating azlocillin-loaded silver nanoparticles for enhanced antibiotic activity and improved wound healing. Azlocillin, a broad-spectrum ß-lactam antibiotic, was combined with silver nanoparticles (AgNPs) to create a hydrogel that provides both sustained antimicrobial effects and promotes tissue regeneration. The hydrogel formulations were prepared using a combination of polyvinyl alcohol (PVA), sodium alginate, and chitosan, crosslinked both physically and chemically. The hydrogels were evaluated for their physical appearance, mechanical properties, pH, drug release profile, antimicrobial activity, and biocompatibility. The results indicated that the PVA-Alginate composite hydrogel exhibited superior performance in terms of drug release, antimicrobial efficacy, and stability over time. The hydrogel formulations demonstrated controlled and sustained release of azlocillin, providing prolonged protection against wound infections. Furthermore, the incorporation of silver nanoparticles enhanced the antimicrobial activity, particularly against common wound pathogens such as Staphylococcus aureus and Pseudomonas aeruginosa. These findings suggest that the developed hydrogel systems have the potential to be an effective and innovative approach for treating chronic wounds and preventing infections in wound healing applications.

Double-crosslinked hydrogel, azlocillin, silver nanoparticles, wound healing, drug delivery, antimicrobial activity, polyvinyl alcohol, sodium alginate, chitosan, infection control


IJTSRD97189
Volume-9 | Issue-4, August 2025
30-34
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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