Formulation and Optimization of Lupeol-Loaded Nanostructured Lipid Carriers for Target Brain Cancer Therapy

Mr. Ashvani Kumar; Shubhangini Singh

Title:
Formulation and Optimization of Lupeol-Loaded Nanostructured Lipid Carriers for Target Brain Cancer Therapy

Authors:
Shubhangini Singh | Mr. Ashvani Kumar

Cite This Article :

Shubhangini Singh | Mr. Ashvani Kumar "Formulation and Optimization of Lupeol-Loaded Nanostructured Lipid Carriers for Target Brain Cancer Therapy" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-9 | Issue-3, June 2025, pp.1390-1396, URL: https://www.ijtsrd.com/papers/ijtsrd97158.pdf

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Abstract :
Targeting brain tumors is challenging due to the restrictive blood–brain barrier (BBB). This study presents Lupeol-loaded nanostructured lipid carriers (NLCs) as a novel approach for brain-targeted delivery. Lupeol, a natural triterpenoid with anticancer and neuroprotective effects, suffers from poor solubility and limited BBB permeability. To enhance its delivery, NLCs were developed using hot homogenization followed by ultrasonication and optimized via Box-Behnken Design. The optimized NLCs showed favorable characteristics: particle size (~142 nm), low PDI (0.218), high entrapment efficiency (89.4%), and sustained drug release (~82% in 72 h). Cellular uptake studies confirmed efficient internalization in U87-MG glioma cells, and cytotoxicity assays showed enhanced anticancer activity over free Lupeol. Intranasal delivery enabled direct nose-to-brain transport via olfactory pathways, bypassing hepatic metabolism. Overall, Lupeol-loaded NLCs represent a promising non-invasive strategy for brain cancer therapy.

Keywords :
Lupeol, nanostructured lipid carriers (NLCs), brain tumor, glioblastoma, intranasal delivery, blood–brain barrier (BBB), targeted drug deliver

Publication Details:

Unique Identification Number : IJTSRD97158

Published In : Volume-9 | Issue-3, June 2025

Page Number(s) : 1390-1396

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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