The prevalent skeletal disorder known as osteoporosis is characterized by decreased bone mineral density and an increased risk of fracture. Even though alendronate, also known as bisphosphonate, is commonly used to treat osteoporosis, oral administration of this drug has been associated with low absorption and gastrointestinal side effects. The aim of this study is to develop and evaluate an alendronate-loaded nanoemulsion to enhance medication permeability and bioavailability. Nanoemulsions are a promising drug delivery technique because of their small droplet size, high solubility, and improved stability. The formulation process involves selecting the appropriate oil, surfactant, and co-surfactant to optimize the nanoemulsion's characteristics. The stability, zeta potential, pH, viscosity, and particle size of the produced nanoemulsion are evaluated. Ex vivo and in vitro investigations evaluate the effectiveness of skin penetration and medication release characteristics. This nanoemulsion-based approach has the potential to improve osteoporosis care, lessen side effects, and increase patient adherence by addressing the drawbacks of traditional oral alendronate therapy. The results of the study help create new, patient-friendly drug delivery strategies for the treatment of osteoporosis.
Osteoporosis, Alendronate, Nanoemulsion, Drug Delivery, Bioavailability, Bone Health
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