Reduced bone mineral density and an elevated risk of fracture are the hallmarks of osteoporosis, a common skeletal condition. Although alendronate, a bisphosphonate, is frequently used to treat osteoporosis, oral administration of this medication is linked to gastrointestinal adverse effects and limited absorption. The objective of this research is to create and assess a nanoemulsion loaded with alendronate in order to improve drug permeability, bioavailability. Nanoemulsions' small droplet size, great solubility, and enhanced stability make them a promising medication delivery method. In order to maximize the properties of the nanoemulsion, the formulation procedure entails choosing the right oil, surfactant, and co-surfactant. The created nanoemulsion is assessed according to its stability, zeta potential, pH, viscosity, and particle size. Ex vivo and in vitro investigations evaluate the effectiveness of skin penetration and medication release characteristics. This nanoemulsion-based approach has the potential to improve osteoporosis care, lessen side effects, and increase patient adherence by addressing the drawbacks of traditional oral alendronate therapy. The results of the study help create new, patient-friendly drug delivery strategies for the treatment of osteoporosis.
Osteoporosis, Alendronate, Nanoemulsion, Drug Delivery, Bioavailability, Bone Health
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