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Formulation Development and Evaluation of Self Nano Emulsifying Drug Delivery System of Dolutegravir

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Formulation Development and Evaluation of Self Nano Emulsifying Drug Delivery System of Dolutegravir


Suresh Mularam Choudhary | Prof S. A Waghmare | Hemant V. Kamble



Suresh Mularam Choudhary | Prof S. A Waghmare | Hemant V. Kamble "Formulation Development and Evaluation of Self Nano Emulsifying Drug Delivery System of Dolutegravir" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5, August 2022, pp.1138-1152, URL: https://www.ijtsrd.com/papers/ijtsrd50569.pdf

The primary objective of the work was to develop a self nano emulsifying drug delivery system of dolutegravir HCL. Self-nanoemulsifying drug delivery system is a lipid based formulation which consists of isotropic mixtures of oils, surfactants and co-surfactants. It can conveniently develop the emulsion on gentle agitation and offers a considerable surface area for interaction between the SNEDDS formulation and the aqueous gastrointestinal fluid. This may lead to enhanced bioavailability of hydrophobic agents. The Liquid SNEDDS was prepared and after that solidified by aerosil 200. For 10 gm of liquid SNEDDS; 5 gm of Aerosil 200 was used and after that product is dried by spray drying method. And 12 gm of product is remaining after the process. The drug-excipients interaction studies were carried out using FTIR and DSC. The interaction studies were carried out to check physical and chemical stability of Dolutegravir with other excipients. FTIR spectra showed the characteristic peaks of drug (i.e. for C-H stretch, N-C stretch) appear in the spectra of physical mixtures at the same wave number indicating no modification or interaction between drug and the polymers. The liquid SNEDDS formulation C1 showed good thermodynamic stability without any precipitation and having globule size 536.6 nm and zeta potential -29.9. Based on thermodynamic stability, precipitation studies, self-emulsification studies, globule size and zeta potential liquid SNEDDS of formulation batch C1 was selected as optimized formulation. Liquid SNEDDS and solid SNEDDS was prepared for Dolutegravir. SEM, IR, and DSC results confirmed that drug was present in an amorphous state in solid SNEDDS. In-vitro drug release and drug content of optimized formulation was found to be 98.64 and 99.35% respectively. F3 batch of capsule formulation shows better drug release than marketed formulation.

Dolutegravir HCL, Self nano emulsifying drug delivery system, Solubility, Lipid


IJTSRD50569
Volume-6 | Issue-5, August 2022
1138-1152
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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