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Formulation Development and Evaluation of Mouth Dissolving Tablet of Thiocolchicoside

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Formulation Development and Evaluation of Mouth Dissolving Tablet of Thiocolchicoside


Sujeet A Korde



Sujeet A Korde "Formulation Development and Evaluation of Mouth Dissolving Tablet of Thiocolchicoside" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5, August 2022, pp.696-713, URL: https://www.ijtsrd.com/papers/ijtsrd50506.pdf

The present study was aimed to formulate and evaluate the Mouth dissolving tablet of Thiocolchicoside. Preliminary investigation of drug was carried out with different. Compatibility of drug with polymers was confirmed by FT-IR study. Tablet were prepared with superdisintegrants like Sodium starch glycolate, and other ingredients such as Mannitol, Lactose, Maltose. Sodium saccharide and Talc by Direct compression technique. It was observed that the results obtained after evaluation of (F2) formulations follows standards prescribed for Mouth dissolving tablets. The tablet was evaluated for various evaluation parameters such as. Weight Variation. Thickness. Hardness, Friability, wetting time, water absorption ratio, In-vitro Disintegration Time, in-Vitro drug release study, and uniformity of Content etc. Mouth dissolving tablet of optimized formulation (F2) having Mouth disintegration, better dissolution and all necessary parameter within the range. Formulation F2 shows the highest drug release upto 99.63%. Finally it is concluded that the drug release from the Mouth dissolving tablet was increased by using the increased concentration of superdisintegrant upto certain conc. After increase in cone. Of superdisintegrant leads to decrease disintegration in the buccal cavity. Increased systemic availability of drug will lead to quick onset of action, which is a prerequisite for analgesic activity.

Thicochicoside, Muscle relexant, MDT tablet, Direct compression method


IJTSRD50506
Volume-6 | Issue-5, August 2022
696-713
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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