The purpose of conducting this study was to prepare a microemulsion formulation of Rosuvastatin calcium (RC) for transdermal drug delivery. Oil in water microemulsion was formulated using Isopropyl myristate, Tween 20, and Propylene Glycol as oil, surfactant, and co-surfactant, respectively. The ideal proportion of surfactant: co-surfactant (Smix) was chosen by constructing pseudoternary diagrams. The microemulsion formulations, which proved to be stable after thermodynamic stability testing, were further evaluated for physical characteristics. Selected formulations were evaluated for droplet size, zeta potential, viscosity, and % drug content. Results suggested that optimized microemulsion formulation was thermodynamically stable and clear, droplet size and zeta potential was determined. In-vitro dissolution study for optimized microemulsion was performed and cumulative % drug release was determined.
Microemulsion, Transdermal drug delivery, Rosuvastatin calcium
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