The solubility behavior of drugs remains one of the most exigent aspects in formulation development. With the advent of combinatorial chemistry and high throughput screening, the number of poorly water soluble compounds has dramatically increased. Among all the newly discovered chemical entities, about 40-45% drugs fail to reach market due to their poor water solubility. Because of solubility problem, bioavailability of drugs gets affected and hence solubility enhancement becomes necessary. In present study the attempts have been made to increase the dissolution of BCS class 2 drug Piroxicam using hydrophilic polymers namely polyethylene glycol (PEG) 6000 and sodium lauryl sulphate as a surfactant by using solid dispersion technique. In solid dispersion microwave induced solid dispersion and conventional fusion method is compared. Drug-polymer complex was prepared using batch method. Maximum dissolution rate was obtained of the complex prepared from (Piroxicam + PEG6000 + SLS). A successful solubility enhancement of drug complex was confirmed by taking drug release in phosphate buffer pH 6.8. The drug was characterized according to different compendial methods, on the basis of identification by UV spectroscopy, organoleptic properties and other tests. After that among the all formulation batches, solid dispersion (F16) was selected for further tablet formulation batches, nine formulations were developed and studied. The values of pre-compression parameters was evaluated, results were within prescribed limits and indicated good free flowing properties. The data obtained of post-compression parameters such as weight variation, hardness, friability, wetting time, water absorption ratio, content uniformity, disintegration time and dissolution was found to superior over conventional formulation. The F9 batch with disintegrating time 10 ± 0.52 second and dissolution 93.20 ± 0.61 % was selected as optimized formulation and was found superior over other formulation. Batch F9 was also subjected to stability studies for three months and was tested for its disintegrating time, drug contents and dissolution behavior monthly. F9 formulation after stability study was found to be stable.
Piroxicam, Solid dispersion, Solubility, Dissolution, Microwave Induced fusion Method
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