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Formulation and Evaluation of Mouth Dissolving Tablets of Losartan Potassium

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Last date : 27-Aug-2022

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Formulation and Evaluation of Mouth Dissolving Tablets of Losartan Potassium


Swapnil Khade | Prof. Mrs. Trusha P. Shangrapawar | Dr. Ashok Bhosale



Swapnil Khade | Prof. Mrs. Trusha P. Shangrapawar | Dr. Ashok Bhosale "Formulation and Evaluation of Mouth Dissolving Tablets of Losartan Potassium" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5, August 2022, pp.32-41, URL: https://www.ijtsrd.com/papers/ijtsrd50408.pdf

Losartan Potassium is an angiotesion II receptor antagonist and used as antihypertensive drug. The molecular weight of Losartan Potassium is 461.0 g/mole, half-life is 1.5 to 2 hours, and its bioavailability is1 25-35%. It gets metabolized mainly in the liver but have good buccal absorption. Mouth dissolving tablets will be the better option for formulation of Losartan Potassium as far as tablet dosage form is concern. Mouth dissolving tablets are soluble in saliva and absorbed from the mouth. thus enhance the bioavailability by avoiding first pass metabolism. Mouth dissolving tablets also leads to an increased patient compliance, and fast onset of action. Mouth dissolving tablets were prepared by direct compression method using natural super disintegrating agents (banana powder) and evaluated for pre-compression parameters and post compression parameters such as appearance, dimensions, hardness, weight variation, friability, wetting time, dispersion time, water absorption ratio, disintegration & dissolution study. According to results of optimized batches it has been concluded that formulation batch F10 was an ideal batch which contain banana powder & crosscarmellose sodium showed least disintegration time that is 61 seconds & maximum drug release of (98.42%) within 10 minutes and was best among all the formulations.

Losartan Potassium, mouth dissolving tablets, natural super disintegrating agent banana powder and synthetic super disintegrating agent crossprovidone and croscarmellose sodium


IJTSRD50408
Volume-6 | Issue-5, August 2022
32-41
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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