The aim of the present work is Formulation and Evaluation of Fast Disintegrating Tablet of Solid Dispersion of Carvedilol. The solid dispersions of Carvedilol were prepared with PEG6000 and PVP K30 in 1:1, 1:2, 1:3 by using Kneading method. The prepared solid dispersions were analyzed for FTIR. Solid dispersions showed a better dissolution compared to the pure drugs and among all the other formulations. The F3 formulation shows high percentage drug release i.e. 96.61% in 40 min and selected as an optimized formulation for the preparation of fast disintegrating tablets of Carvedilol. Crosscarmellose sodium and Crospovidone used in the preparation of fast disintegrating tablets prepared by direct compression method. The post compression parameters of all the prepared tablets were within the limits. FD6 was selected as optimized formulation based on its highest disintegration time 48 sec and drug release 94.87% in 40 min. Hence it concluded that solid dispersions incorporated fast disintegrating tablets is very useful approach for fast disintegration of Carvedilol to treat high blood pressure.
Solid dispersion, Carvedilol, Kneading method, Bioavailability
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