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Formulation and Evaluation of Fast Disintegrating Tablet of Solid Dispersion of Carvedilol - A Research

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Volume-6 | Issue-5

Last date : 27-Aug-2022

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Formulation and Evaluation of Fast Disintegrating Tablet of Solid Dispersion of Carvedilol - A Research


Akshada Gavhane | Prof. Mr. Prashant Khade | Dr. Ashok Bhosale



Akshada Gavhane | Prof. Mr. Prashant Khade | Dr. Ashok Bhosale "Formulation and Evaluation of Fast Disintegrating Tablet of Solid Dispersion of Carvedilol - A Research" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5, August 2022, pp.60-74, URL: https://www.ijtsrd.com/papers/ijtsrd50379.pdf

The aim of the present work is Formulation and Evaluation of Fast Disintegrating Tablet of Solid Dispersion of Carvedilol. The solid dispersions of Carvedilol were prepared with PEG6000 and PVP K30 in 1:1, 1:2, 1:3 by using Kneading method. The prepared solid dispersions were analyzed for FTIR. Solid dispersions showed a better dissolution compared to the pure drugs and among all the other formulations. The F3 formulation shows high percentage drug release i.e. 96.61% in 40 min and selected as an optimized formulation for the preparation of fast disintegrating tablets of Carvedilol. Crosscarmellose sodium and Crospovidone used in the preparation of fast disintegrating tablets prepared by direct compression method. The post compression parameters of all the prepared tablets were within the limits. FD6 was selected as optimized formulation based on its highest disintegration time 48 sec and drug release 94.87% in 40 min. Hence it concluded that solid dispersions incorporated fast disintegrating tablets is very useful approach for fast disintegration of Carvedilol to treat high blood pressure.

Solid dispersion, Carvedilol, Kneading method, Bioavailability


IJTSRD50379
Volume-6 | Issue-5, August 2022
60-74
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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