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Formulation Development and In-Vitro Evaluation of Microsponge Drug Delivery System of Antifungal Drug

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Formulation Development and In-Vitro Evaluation of Microsponge Drug Delivery System of Antifungal Drug


Vilas S. Bhagat | Sanjay R. Arote



Vilas S. Bhagat | Sanjay R. Arote "Formulation Development and In-Vitro Evaluation of Microsponge Drug Delivery System of Antifungal Drug" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-3, April 2021, pp.654-661, URL: https://www.ijtsrd.com/papers/ijtsrd39870.pdf

A Microsponge Delivery System (MDS) is patented, highly cross-linked, porous, polymeric microspheres that can entrap wide range of actives and then release them onto the skin over a time and in response to trigger. It is a unique technology for the controlled release of topical agents and consists of microporous beads, typically 10-25 microns in diameter, loaded with active agent. In this study, Ketoconazole microsponges were prepared by using quasi-emulsion solvent diffusion method. The microsponges thus prepared, were evaluated for production yield, loading efficiency, particle size analysis, in-vitro release study of microsponges, and stability. Hence, the present work concluded that MDS has a great potential in topical delivery of drugs like Ketoconazole, with added advantage of reduction in irritation profile due to the controlled release and possible enhancement in the activity due to amorphization of the drug.

Microsponge, microporous beads, particle size analysis


IJTSRD39870
Volume-5 | Issue-3, April 2021
654-661
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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