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A General Review on Bioanalytical Method Development & Validation for LC-MS/MS

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A General Review on Bioanalytical Method Development & Validation for LC-MS/MS


Ashutosh Badola | Preeti Joshi | Preeti Kothiyal

https://doi.org/10.31142/ijtsrd14203



Ashutosh Badola | Preeti Joshi | Preeti Kothiyal "A General Review on Bioanalytical Method Development & Validation for LC-MS/MS" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-4, June 2018, pp.1340-1347, URL: https://www.ijtsrd.com/papers/ijtsrd14203.pdf

Rapid growth in the use of LC-MS/MS for the analysis of drugs in biological matrices has been compelled by the need for timely and high-quality data at every stages in drug discovery and development process: from throughput screening of drug candidates and rapid data generation for pre-clinical studies to almost 'real-time' analysis of clinical samples. A well developed bioanalytical development and its validation plays a pivotal role in achieving the goals. . The aim behind this review is to enlighten the need of validation which provide a practical approach for determining the different parameters like selectivity, specifity, limit of detection, lower limit of quantitation, linearity, range, accuracy, precision, recovery, stability, ruggedness, and robustness to help the perfect studies of pharmacokinetic, toxic kinetic, bioavailability and bioequivalence. Bio-analysis study is for the quantitative determination of drug and their metabolites in biological fluids. Accurate and robust methods for quantitative analysis of drug and their metabolites are important for the successful conduct of pre-clinical, bio-pharmaceutics and clinical pharmacology.

LC-MS/MS bioanalysis , Bio-analytical method development,Validation parameters, sample Preparation LLE, SPE


IJTSRD14203
Volume-2 | Issue-4, June 2018
1340-1347
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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