Background: Inflammation is a reaction of living tissues towards injury. The complex biological reaction to harmful agents such as microbes, pathogens, damaged cells that contain vascular responses, activation of leukocytes and various systemic reactions causes inflammation. So, number of herbal medicine is recommended for the treatment of inflammation that has no side effects. Triphala, an Ayurvedic formula composed of three different drugs. Terminalia chebula Retz, Terminalia bellerica Roxb and Emblica officinalis Linn is widely used for various microbial infections and inflammation. Aims and Objectives: To evaluate anti-inflammatory activity of Triphala ointment. Methods: Triphala is now evaluated for its anti-inflammatory action. Triphala is formulated into a ointment of different concentrations and is evaluated for in-vivo anti inflammatory activity by 1:1:1 and 1:2:4 combination, In-vivo evaluation is done by Carrageenan induced paw edema method. The results obtained are compared with standard NSAID Diclofenac ointment.Results: When test drug treated groups are compared with standard group, Triphala ointment 1:1:1 and Triphala ointment 1:2:4 showed significant effect 3 hours onwards to 5 hours with a mean value 0.07833±0.06555 (89.34%), 0.1±0.105 (86.39%) and 0.08333±0.06501 (88.70%) respectively.Conclusion: In this study, Triphala ointment with 1:2:4 combinations showed better anti-inflammatory activity (88.70%) when compared to Triphala ointment 1:1:1(86.39%) in the reduction of rat paw volume.
Anti-inflammatory activity, Triphala ointment
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