Mouth dissolving films, are now becoming more popular than fast-dissolving tablets. They are most advanced oral solid dosage form due to its flexibility and comfort in use. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. Geriatric and pediatric patients are facing difficulty in swallowing of tablet and capsule, the oral film can bypass it, along with that it has other advantages like self-administrable, fast dissolving, rapid absorption that make it versatile dosage form. The aim of present study is to enlighten specifically different polymer along with their concentrations and applications The oral buccal mucosa being highly vascularized, drugs can absorbed directly and can enter the systemic circulation without undergoing first-pass hepatic metabolism. This advantage can be exploited in preparing products with improved oral bioavailability of molecules that undergo first pass effect. The sublingual and buccal delivery of a drug via thin film has the potential to improve the onset of action, lower the dosing and enhance the efficacy and safety profile of medicament. An ideal film should have the properties like pleasant taste, high stability and ease of handling. This study also focuses on use of plasticizer, polymer, sweetener, different methods which are used for the preparation of oral films and various evaluation parameter of the film. It is evaluated for its various parameters like thickness, physical property like folding endurance, disintegration and dissolution time. The polymer used in mouth dissolving films is crucial to their quick dissolution and disintegration. The polymer must be non-toxic, non-irritating, flavourless, and simple to use. Natural and synthetic polymers are the two types of polymers that are employed. Natural polymers used in formulation of film include chitosan, gaur gum, xanthan gum, soy polysaccharide, gellan gum, locust bean gum, maltodextrin, and rosin. Hydroxypropyl cellulose, polyvinyl pyrrolidone, Hydroxypropyl Methylcellulose, Polyethylene Oxide, and Polyvinyl Alcohol are synthetic polymers that are frequently used to make films.
Introduction, Ideal Characteristics, Method of preparation, Evaluation parameter
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