The purpose of this study was to formulate and evaluate conventional tablets of Ibuprofen HCl with Castor oil. Castor oil helps to overcome the hepatotoxic effect of Ibuprofen HCl. Direct compression method was used to formulate tablets, which contained Castor oil in different proportion from batch F1-F4. Formulation of tablets was prepared by the powder blend of different ratios of Castor oil to get desirable drug release profile. All batches were evaluated for flow property (Pre compression study). Evaluation parameters of formulated tablets were hardness, friability, thickness, drug content, weight variation, and the in-vitro drug release rate pattern. Results indicated that the formulation F2 was the most promising formulation as the drug release from this formulation was high as compared to other formulations. In formulation F2, percentage drug release of Ibuprofen HCl is 97.01% at 60 min.
Ibuprofen HCl, Castor oil, Conventional tablet, NSAIDs, Direct Compression
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