The purpose of this study was to formulate and evaluate bilayer tablets of sustained release Nifedipine layer for hypertension and Pioglitazone HCl immediate release layer for Diabetes. Direct compression method was used to formulate bilayer tablets, which contained HPMC E4M as a sustained release polymer and super disintegrating agent such as Croscarmellose sodium in different proportion from batch F1-F4. Formulation of bilayer tablets was prepared by the FP1-FP4 and FN1-FN4 powder blend of different ratios of polymer to get desirable drug release profile. Evaluation parameters of formulated bilayer tablets were hardness, friability, thickness, drug content, weight variation, and the in-vitro drug release rate pattern results indicated that the formulation F4 was the most promising formulation as the drug release from this formulation was high as compared to other formulations. In formulation F4, percentage drug release of Nifedipine sustained release layer was 98.94% at 12 hrs. and 98.89% at 60 min for Pioglitazone HCl immediate release layer.
Nifedipine, Pioglitazone, Bilayer Tablets, Sustained Release, Immediate Release
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