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Formulation & Evaluation of Bilayer Tablets of Sustained Release Nifedipine Layer and Immediate Release Pioglitazone Layer

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Volume-6 | Issue-6

Last date : 26-Oct-2022

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Formulation & Evaluation of Bilayer Tablets of Sustained Release Nifedipine Layer and Immediate Release Pioglitazone Layer


Pankaj Mane | Sujit Kakade | Ashok Bhosale



Pankaj Mane | Sujit Kakade | Ashok Bhosale "Formulation & Evaluation of Bilayer Tablets of Sustained Release Nifedipine Layer and Immediate Release Pioglitazone Layer" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-4, June 2022, pp.1774-1785, URL: https://www.ijtsrd.com/papers/ijtsrd50388.pdf

The purpose of this study was to formulate and evaluate bilayer tablets of sustained release Nifedipine layer for hypertension and Pioglitazone HCl immediate release layer for Diabetes. Direct compression method was used to formulate bilayer tablets, which contained HPMC E4M as a sustained release polymer and super disintegrating agent such as Croscarmellose sodium in different proportion from batch F1-F4. Formulation of bilayer tablets was prepared by the FP1-FP4 and FN1-FN4 powder blend of different ratios of polymer to get desirable drug release profile. Evaluation parameters of formulated bilayer tablets were hardness, friability, thickness, drug content, weight variation, and the in-vitro drug release rate pattern results indicated that the formulation F4 was the most promising formulation as the drug release from this formulation was high as compared to other formulations. In formulation F4, percentage drug release of Nifedipine sustained release layer was 98.94% at 12 hrs. and 98.89% at 60 min for Pioglitazone HCl immediate release layer.

Nifedipine, Pioglitazone, Bilayer Tablets, Sustained Release, Immediate Release


IJTSRD50388
Volume-6 | Issue-4, June 2022
1774-1785
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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