This review article covers the detailed about cubosome. Cubosomes are single crystal structures, with visible unilamellar vesicles, dispersed lamellar liquid crystalline phase particles. Increasing polymer-to-monoolein ratios leads to formation of larger vesicles. Cubosomes are nanoparticles whose size ranges from 10-50nm in diameter they appear like dots square shaped, slightly spherical. Each dot corresponds to the presence of pore containing aqueous phase cubic phases in lipid water system in X-ray scattering technique. and also covers some methods of preparation of cubosome along with there characterization methods like Cryo-Transmission Electron Microscopy (Cryo-TEM), Small-Angle X-ray Scattering (SAXS), Particle Size Distribution (PSD). Application of cubosome like vehicle activity of biological substances, controlled release of solubilized substances, Treatment of skin, hair, and other body tissue. Melanoma (cancer) therapy on size delivery system is the key to target cancer through the enhanced permeability and retention effect. With some advantages of cubosome.
Cubosome, Monoolein, cubic phases, Suspension, Nanopartical
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