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Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL

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Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL


Zeenath Ruhy



Zeenath Ruhy "Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1, December 2019, pp.847-852, URL: https://www.ijtsrd.com/papers/ijtsrd29702.pdf

Metaclopromide-HCl is an Anti-emetic used to treat nausea, vomiting and to increase gastric motility. The present work aimed at preparing oral fast dissolving films of Metaclopromide-HCl with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral fast dissolving films of Metaclopromide-HCl were prepared using HPMC (E5, E15) polymers as film forming agents and polyethylene glycol-400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug and excipients. Dissolution of prepared fast dissolving oral films of Metaclopromide-HCl was performed using USP type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being maintained at 37 0.5º C. The films prepared were evaluated for various parameters like thickness, drug content uniformity, weight variation, disintegration time, folding endurance and in vitro drug release and were showed satisfactory results. In conclusion, development of oral fast dissolving oral films using HPMC polymer gives rapid drug delivery and rapid onset of action.

Oral fast dissolving films, Metaclopromide, HPMC


IJTSRD29702
Volume-4 | Issue-1, December 2019
847-852
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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