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Effect on Binary & Ternary Inclusion of Ibuprofen & Different Amino Acid Complex on Phase Solubility

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Last date : 27-Aug-2024

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Effect on Binary & Ternary Inclusion of Ibuprofen & Different Amino Acid Complex on Phase Solubility


Ms. Chetana D. Patil | Mr. Vaibhav C. Babar | Ms. Prajakta S. Kakade



Ms. Chetana D. Patil | Mr. Vaibhav C. Babar | Ms. Prajakta S. Kakade "Effect on Binary & Ternary Inclusion of Ibuprofen & Different Amino Acid Complex on Phase Solubility" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-4, June 2022, pp.851-854, URL: https://www.ijtsrd.com/papers/ijtsrd50151.pdf

The aim of present research was to formulate and characterize inclusion complexes between ß-cyclodextrin (ß-CD) and Ibuprofen. Equimolar/ ß-CD solid system in the presence and absence of 0.2% (w/v) ß-CD was prepared. A phase solubility study was done to estimate solubility constant (KS) and complexation efficiency (CE). Improvement of KS and CE showed the additive effect of auxiliary substances (ß-CD). The dissolution properties of binary and ternary systems were determined and compared with alone. The ternary system has shown several times faster than the binary system of Ibuprofen. The optimized binary and ternary systems were characterized by phase solubility. These results showed that ternary inclusion complexes were formed.

Ibuprofen, ß-cyclodextrin leucine, glycine, Stability constant


IJTSRD50151
Volume-6 | Issue-4, June 2022
851-854
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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