Effect on Binary & Ternary Inclusion of Ibuprofen & Different Amino Acid Complex on Phase Solubility

Mr. Vaibhav C. Babar; Ms. Prajakta S. Kakade; Ms. Chetana D. Patil

Title:
Effect on Binary & Ternary Inclusion of Ibuprofen & Different Amino Acid Complex on Phase Solubility

Authors:
Ms. Chetana D. Patil | Mr. Vaibhav C. Babar | Ms. Prajakta S. Kakade

Cite This Article :

Ms. Chetana D. Patil | Mr. Vaibhav C. Babar | Ms. Prajakta S. Kakade "Effect on Binary & Ternary Inclusion of Ibuprofen & Different Amino Acid Complex on Phase Solubility" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-4, June 2022, pp.851-854, URL: https://www.ijtsrd.com/papers/ijtsrd50151.pdf

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Abstract :
The aim of present research was to formulate and characterize inclusion complexes between ß-cyclodextrin (ß-CD) and Ibuprofen. Equimolar/ ß-CD solid system in the presence and absence of 0.2% (w/v) ß-CD was prepared. A phase solubility study was done to estimate solubility constant (KS) and complexation efficiency (CE). Improvement of KS and CE showed the additive effect of auxiliary substances (ß-CD). The dissolution properties of binary and ternary systems were determined and compared with alone. The ternary system has shown several times faster than the binary system of Ibuprofen. The optimized binary and ternary systems were characterized by phase solubility. These results showed that ternary inclusion complexes were formed.

Keywords :
Ibuprofen, ß-cyclodextrin leucine, glycine, Stability constant

Publication Details:

Unique Identification Number : IJTSRD50151

Published In : Volume-6 | Issue-4, June 2022

Page Number(s) : 851-854

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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