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RP-HPLC Method Developed for the Estimation of Etodolac and Thiocolchicoside in Bulk and Combined Dosage Forms

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RP-HPLC Method Developed for the Estimation of Etodolac and Thiocolchicoside in Bulk and Combined Dosage Forms


Prapulla Putta



Prapulla Putta "RP-HPLC Method Developed for the Estimation of Etodolac and Thiocolchicoside in Bulk and Combined Dosage Forms" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1, December 2019, pp.853-863, URL: https://www.ijtsrd.com/papers/ijtsrd29703.pdf

A new, simple, specific, sensitive, rapid, accurate and precise RP-HPLC method was developed for the estimation of Etodolac (ETO) and Thiocolchicoside (THIO) in bulk and combined pharmaceutical dosage forms. Etodolac (ETO) and Thiocolchicoside (THIO) was chromatographed on a Symmetry ODS C18 (4.6mm×250mm, 5µm) Column in a mobile phase consisting of Acetonitrile: Methanol: Acetate Buffer (25:20:55% v/v). The mobile phase was pumped at a flow rate of 1.0 ml/min with detection at 238 nm. The detector response was linear in the concentration of 200-600µg/ml 20-60µg/ml for Etodolac and Thiocolchicoside respectively. The intra and inter day variation was found to be less than 2%. The mean recovery of the drug from the solution was 99.98%. The developed method was validated for sensitivity, accuracy, precision, ruggedness and robustness. The % RSD results for precision and intermediate precision found less than 2.0%. The LOD and LOQ were found to be 0.86 and 1.18 µg/ml for Etodolac and 2.4 and 3.54µg/ml for Thiocolchicoside respectively. The proposed method is simple, fast, accurate, precise and reproducible hence; it can be applied for routine quality control analysis of Etodolac (ETO) and Thiocolchicoside (THIO) in bulk and combined pharmaceutical formulations.

: Accuracy, Etodolac, Precision, RP-HPLC, Thiocolchicoside and Validation


IJTSRD29703
Volume-4 | Issue-1, December 2019
853-863
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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