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Determination of Etodolac in Commercial Formulations by HPLC-UV Method

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Determination of Etodolac in Commercial Formulations by HPLC-UV Method


Tugrul Cagri Akman | Yucel Kadioglu



Tugrul Cagri Akman | Yucel Kadioglu "Determination of Etodolac in Commercial Formulations by HPLC-UV Method" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1, December 2019, pp.128-132, URL: https://www.ijtsrd.com/papers/ijtsrd29452.pdf

The aim of this study was to develop and verify a simple, rapid and sensitive high performance liquid chromatography method coupled with UV detector (HPLC-UV) method for the quantitative determination of etodolac in bulk and pharmaceutical dosage forms. Chromatographic separation was performed at ambient conditions on a reverse phase ACE C8 analytical column (250 mm x 4.6 mm ID, 5 umm) using the mobile phase containing acetonitrile-water (80:20, v/v) at a flow rate of 1.0 mL min-1. A wavelength of 272 nm was used for etodolok and paracetamol (IS). A retention time of 4.21 min and 2.02 min were obtained for etodolac and IS, respectively. The method showed linearity in the range of 0.08-10 µg mL-1 for etodolac (R = 0.9999). The linear regression equations obtained by least square regression method were the ratio of peak area of etodolac and IS =1.559 concentration (etodolac µg/mL) - 0.139. The intra-day and inter-day RE% and RSD% values of the method were =10.0% and =2.65%, respectively. Limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.04 and 0.06 µg mL-1 for etodolac, respectively. A new, simple and sensitive high performance liquid chromatography method was developed and validated for etodolac. The method can be applied for the quantification of etodolac without derivatization in bulk solutions and commercial formulations using the internal standard.

HPLC, etodolac, validation, formulation


IJTSRD29452
Volume-4 | Issue-1, December 2019
128-132
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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