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Analytical Methods Development and Validation of Naproxen and Sumatriptan by RP HPLC

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Analytical Methods Development and Validation of Naproxen and Sumatriptan by RP HPLC


Prapulla Putta

https://doi.org/10.31142/ijtsrd23582



Prapulla Putta "Analytical Methods Development and Validation of Naproxen and Sumatriptan by RP HPLC" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4, June 2019, pp.325-327, URL: https://www.ijtsrd.com/papers/ijtsrd23582.pdf

Aim and objective: A simple, précised, accurate method was developed for the estimation of Crizotinib by RP-HPLC technique. Chromatographic conditions used are stationary phase BDS 250x4.6 mm, 5µ. Mobile phase buffer: Methodology: Acetonitrile in the ratio of 60;40 and flow rate was maintained at1ml/min, detection wave length was 267 nm, column temperature was set to 30o C and diluents was methanol: water System suitability parameters were studied by injecting the standard five times and results were well (50:50), Results & Discussion: Conditions were finalized as optimized method under acceptance criteria. Linearity study was carried out between 25 % to 150 % levels, r2 value was found to be as 0.999. Precision was found to be 1.26 for repeatability and 0.93 for intermediate precision. LOD and LOQ are 0.080 ug/ml. By using above method assay of marketed formulation was carried out 100.24 % was present.

Crizotinib, HPLC, ICH Guidelines, Method development


IJTSRD23582
Volume-3 | Issue-4, June 2019
325-327
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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