Titrimetric Analysis of Acelofenec Sodium by using Mixed Solvency

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/ by/4.0) ABSTRACT Titration is a method of quantitative/chemical analysis which can be used to determine the concentration of a known reactant. Mixed solvency has been widely used to enhance the aqueous solubility of a large number of poorly watersoluble drugs. Various organic solvents like methanol, chloroform, dimethyl formamide and ethanol have been employed for solubilization of poorly watersoluble drugs. Organic solvents because of their higher cost, toxicities and pollution are not used as solvent. In the present investigation a sodium benzoate, sodium citrate, sodium salicylate solution (an economic agent) was employed as a hydrotropic solubilizing agent to solubilize the poorly water-soluble drug aceclofenac for its titrimetric analysis in bulk sample and tablets precluding the use of organic solvent. The proposed method is new, simple, precise and inexpensive. The results of the analysis have been validated statistically. The mean % recoveries were found to be close to 100, indicating the accuracy of the proposed method.


INTRODUCTION
Titration is a method of quantitative/chemical analysis which can be used to determine the concentration of a known reactant. Because volume measurements play a key role in titration, the titrant, of known concentration (a standard solution) and volume is used to react with a measured quantity of reactant (analyte).
By using a calibrated burette to add the titrant, it is possible to determine the exact amount that has been consumed when the endpoint is reached. The endpoint is the point in which the titration is stopped. This is a point at which the number of moles of titrant is equal to the number of moles of analyte. In the strong acid-strong base titration the endpoint of a titration is when the pH of the reactant is just about equal to 7, and often when the solution permanently changes color due to an indicator. Many methods can be used to indicate the endpoint of a reaction; titrations often use visual indicators (the reactant mixture changes colour). In simple acid-base titrations a pH indicator may be used, such as phenolphthalein, which turns (and stays) pink when a certain pH is reached or exceeded. Methyl orange can also be used, which is red in acids and yellow in alkalis. 1,2 Not every titration requires an indicator. In some cases, either the reactants or the products are strongly coloured and can serve as the "indicator". For example, an oxidationreduction titration using potassium permanganate (pink/purple) as the titrant does not require an indicator. When the titrant is reduced, it turns colourless. After the equivalence point, there is excess titrant present. The equivalence point is identified from the first faint pink colour that persists in the solution being titrated.

Acid base titration:
An acid-base titration is method of quantitative analysis for determining the concentration of an acid or base by exactly neutralizing it with a standard solution of base or acid having known concentration. A pH indicator is used to monitor the progress of the acid-base reaction. If the acid dissociation constant (pKa) of the acid or base in the analyte solution is known, its solution concentration (molarity) can be determined. Alternately, the pKa can be determined if the analyte solution has a known solution concentration by constructing a titration curve.

Alkalimetry and acidimetry:
Alkalimetry and acidimetry are a kind of volumetric analysis in which the fundamental reaction is a neutralization reaction. Alkalimetry is the specialized analytic use of acidbase titration to determine the concentration of a basic (synonymous to alkaline) substance. Acidimetry, sometimes spelled acidometry, is the same concept of specialized analytic acid-base titration, but for an acidic substance.

Hydrotrophy / mixed solvency:
Hydrotropy refers to the ability of a concentrated solution of a chemical compound to increase the aqueous solubility of another compound [usually a sparingly soluble organic

Aceclofenac:
Aceclofenac [[2-(2', 6'-dichlorophenyl) amino] phenyl acetoxy acetic acid] is a phenyl acetic acid derivative belongs to the group of non-steroidal anti-inflammatory drug (NSAID). It is a pro-drug of diclofenac, and decomposed under hydrolytic stress (neutral, acidic, and alkaline) and also on exposure to light (in solution form).It is used as antirheumatic, anti-inflammatory (both acute and chronic), analgesic (effective pain killer in lower backache, dental or gynecological pain) and antipyretic. Dysmenorrhea it is effective to treat dysmenorrheal pain. A single oral dose of aceclofenac 100 mg is sufficient to reduce primary dysmenorrhoea. In addition combination of aceclofenac and drotaverine is also functional and well tolerated treatment choice for primary dysmenorrhoea. We know that 1ml of NaOH contain35.3mg of Acelofenac So 5.59×35.5=197.32mg It means total contain of drug 197.32mg

Conclusion:
Titrimetric analysis by using mixed solvency compared very well with the results of Pharmacopeia method.The Proposed method of analysis is new, simple, accurate, environmentally friendly and reproducible.In this concluded that the proposed method is simple, cost-effective, accurate, safe, precise, and can be successfully employed in routine analysis of aceclofenac bulk drug as well as aceclofenac tablets. There is good scope for other poorly water-soluble drugs which may be solubilized by hydrotropic agents to carry out titrimetric analysis, precluding the use of costlier and unsafe organic solvents.