Home > Medicine > Physiology > Volume-3 > Issue-4 > Physiological Functions of LMP2/B1i in the Female Reproductive System

Physiological Functions of LMP2/B1i in the Female Reproductive System

Call for Papers

Volume-4 | Issue-5

Last date : 27-Aug-2020

Best International Journal
Open Access | Peer Reviewed | Best International Journal | Indexing & IF | 24*7 Support | Dedicated Qualified Team | Rapid Publication Process | International Editor, Reviewer Board | Attractive User Interface with Easy Navigation

Journal Type : Open Access

Processing Charges : 700/- INR Only OR 25 USD (for foreign users)

Paper Publish : Within 2-4 Days after submitting

Submit Paper Online

For Author

IJTSRD Publication

Research Area


Physiological Functions of LMP2/B1i in the Female Reproductive System


Takuma Hayashi | Kenji Sano | Tomoyuki Ichimura | Gal Gur | Hiroyuki Aburatani | Yae Kanai | Dorit Zharhary | Susumu Tonegawa | Nobuo Yaegashi | Ikuo Konishi

https://doi.org/10.31142/ijtsrd23892



Takuma Hayashi | Kenji Sano | Tomoyuki Ichimura | Gal Gur | Hiroyuki Aburatani | Yae Kanai | Dorit Zharhary | Susumu Tonegawa | Nobuo Yaegashi | Ikuo Konishi "Physiological Functions of LMP2/B1i in the Female Reproductive System" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4, June 2019, pp.597-600, URL: https://www.ijtsrd.com/papers/ijtsrd23892.pdf

The ubiquitin proteasome system (UPS) is essential for many cellular processes, including the cell cycle, the regulation of gene expression and cell survival. Dysfunctional UPS can be associated with the underlying pathophysiology of specific diseases. The 20S proteasome core is composed of 28 subunits, which are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven ? subunits, and the two central rings are each formed by seven ? subunits. The The over expression of LMP2/?1i in trophoblast cells of hydatidiform moles may contribute to its highly invasive phenotype. LMP2/?1i-deficient mice reportedly exhibit uterine neoplasms, with a disease prevalence of 36% by 12 months of age. Embryo implantation involves the invasion of placental extravillous trophoblast cells (EVTs) into the uterus. Normal human placentas or placentas from hydatidiform mole patients were collected and the expression of LMP2/?1i in different cell types including trophoblastic column (TC), cytotrophoblast cells (CTB) and syncytiotrophoblasts (STBs) was examined under different pathological states by pathological analysis. The expression of LMP2/?1i in TC of partial hydatidiform mole and complete hydatidiform mole placentas, was higher than that in TC of normal human placentas. Further the experiments with human and mouse uterine tissues clarified the physiological significance of LMP2/?1i in malignant myometrium transformation. In this mini review, we covered recent insights into the molecular pathways involved in LMP2/?1i-mediated physiological functions, with a particular focus on embryo implantation and uterine mesenchymal tumorigenesis.

LMP2/?1i, implantation, trophoblast, leiomyosarcoma, leiomyoma


IJTSRD23892
Volume-3 | Issue-4, June 2019
597-600
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

Thomson Reuters
Google Scholer
Academia.edu

ResearchBib
Scribd.com
archive

PdfSR
issuu
Slideshare

WorldJournalAlerts
Twitter
Linkedin