Home > Medicine > Physiology > Volume-3 > Issue-2 > Gongronema Latifolium: A Plant with Cardioprotective Potentials

Gongronema Latifolium: A Plant with Cardioprotective Potentials

Call for Papers

Volume-4 | Issue-5

Last date : 27-Aug-2020

Best International Journal
Open Access | Peer Reviewed | Best International Journal | Indexing & IF | 24*7 Support | Dedicated Qualified Team | Rapid Publication Process | International Editor, Reviewer Board | Attractive User Interface with Easy Navigation

Journal Type : Open Access

Processing Charges : 700/- INR Only OR 25 USD (for foreign users)

Paper Publish : Within 2-4 Days after submitting

Submit Paper Online

For Author

IJTSRD Publication

Research Area


Gongronema Latifolium: A Plant with Cardioprotective Potentials


Justin Atiang Beshel | Favour Nyoh Beshel | Clement Oshie Nku | Daniel Udofia Owu

https://doi.org/10.31142/ijtsrd21431



Justin Atiang Beshel | Favour Nyoh Beshel | Clement Oshie Nku | Daniel Udofia Owu "Gongronema Latifolium: A Plant with Cardioprotective Potentials" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-2, February 2019, pp.548-558, URL: https://www.ijtsrd.com/papers/ijtsrd21431.pdf

Gongronema latifolium (GL) has gained research interest in the field of Medicine. The present study investigated the cardioprotective potentials of the ethanolic and ethyl acetate fraction of the leaves extract of G.L. 18 Male Wistar rats were divided equally into three groups. Group 1 was the control group, and was administered 0.9% normal saline. Group 2 was administered 200mg/kg ethanolic leaves extract of GL. Group 3 received 200mg/kg ethyl acetate fraction of the leaves extract of GL. Administration was via oral gavage and lasted for 14 days. The rats were sacrificed under chloroform anaesthesia. Blood was collected via cardiac puncture, allowed to clot, and later centrifuged to get serum. Laboratory assays were done for serum concentrations of total cholesterol (Tc), total triglycerides (Tg), high density lipoprotein (HDL-c), low density lipoprotein (LDL), malondialedyde (MDA), total antioxidant capacity (TAC), and total plasma peroxide (TPP). The heart, aorta, and kidneys were also harvested for organ weight and histological studies. Administration of GL extracts resulted in an increase (p<0.001) serum concentrations of HDL-c and TAC, with a consequent reduction in the serum concentrations of Tg, LDL-c, VLDL, MDA, and TPP. There was no significant (p<0.01) change in organ weights of the heart, aorta, and kidneys across the groups. Histology of the blood vessels showed intact layers across the groups. There was no derangement of cellular architecture in the heart and kidney. This study therefore concludes that Gongronema latifolium leaves extract is cardioprotective, and thus provides a basis for the use of this plant as an alternative for the prevention, management or control of cardiovascular diseases.

Cardioprotection, Gongronema latifolium, Cardiovascular diseases


IJTSRD21431
Volume-3 | Issue-2, February 2019
548-558
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

Thomson Reuters
Google Scholer
Academia.edu

ResearchBib
Scribd.com
archive

PdfSR
issuu
Slideshare

WorldJournalAlerts
Twitter
Linkedin