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Effects of Aqueous Leaf Extract of Cashew (Anacardium Occidentale) on Paracetamol Induced Hepatotoxicity of Adult Male Wistar Rats

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Volume-3 | Issue-4

Last date : 26-Jun-2019

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Effects of Aqueous Leaf Extract of Cashew (Anacardium Occidentale) on Paracetamol Induced Hepatotoxicity of Adult Male Wistar Rats


Okonkwo, C. O. J | Oguaka V.N. | Edeh, A.I.


Okonkwo, C. O. J | Oguaka V.N. | Edeh, A.I. "Effects of Aqueous Leaf Extract of Cashew (Anacardium Occidentale) on Paracetamol Induced Hepatotoxicity of Adult Male Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-3, April 2018, pp.8-26, URL: https://www.ijtsrd.com/papers/ijtsrd10756.pdf

While paracetamol is described as relatively nontoxic when administered in therapeutic doses, it is known to cause toxicity when taken in a single or repeated high dose, or after chronic ingestion. Adverse events typically associated with paracetamol intoxication include acute liver failure (ALF), centrilobular hepatic necrosis, renal tubular necrosis and hypoglycemic coma.Cashew (Anacardium occidentale) has been used both as source of nutrition and medicinally worldwide.A total of 25 adult male Wistar rats weighing 100g-200g were used for this study. The animals were divided into 5 groups of 5 rats each. 1000mg/kg/body weight of paracetamol was given for 3 days to induce liver damage in groups B-E. Group A served as the normal control group and received feed and water throughout the period of the experiment. Group B served as negative control group and received feeds and water throughout the period of the experiment, but no treatment with the extract. Group C, D and E received 150mg, 300mg and 500mg/kg of the extract for 21 days. All data obtained were subjected to statistical analysis using t-test, one-way ANOVA and POST HOC LSD using SPSS version 20. Differences between means were regarded significant at P<0.05. Data were expressed as mean + standard error of mean (SEM).The result showed a significant increase in AST in Group E (P<0.05) when compared to Group A. However, there was a decrease in Group C when compared to Group B. Also, there was a significant increase in ALT in Group D (P<0.05) and Group E (P<0.05), when compared to Group A. However, there was a decrease in Group C for both AST and ALT when compared to Group B.From this study, it can be said that aqueous leaf extract of Anacardium occidentale has a little correction effect on Paracetamol induced hepatotoxicity in small doses. However, it can exert a serious toxic effect on the liver with increased dosage.

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IJTSRD10756
Volume-2 | Issue-3, April 2018
8-26
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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