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Effect of A Standard Anti-Tuberculosis Regimen on Hematological Parameters and Serum Protein Level in Male Wistar RATS

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Effect of A Standard Anti-Tuberculosis Regimen on Hematological Parameters and Serum Protein Level in Male Wistar RATS


Okonkwo, C. O. J | Maduka, S. O | Orji, E. I

https://doi.org/10.31142/ijtsrd10691



Okonkwo, C. O. J | Maduka, S. O | Orji, E. I "Effect of A Standard Anti-Tuberculosis Regimen on Hematological Parameters and Serum Protein Level in Male Wistar RATS" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-2, February 2018, pp.1689-1712, URL: https://www.ijtsrd.com/papers/ijtsrd10691.pdf

Despite the Global effort that have been intensified greatly, especially over the past two decades, the incidence of tuberculosis is in increase with about 2 billion infected individuals (WHO, 2014). This work sorts to add to the available knowledge of the effects anti-tuberculosis drugs have on various physiological systems with specific interest on the hematological parameters and serum protein level. This study was carried out using 24 male wistar rats weighing within the range of 150-200 g. These animals were randomly separated into four groups of eight rats each. One of these groups is the control group (fed with just feed and water) and the other two groups (labeled group1 and group 2) are the experimental groups receiving an administration of 22.5mg/kg and 45mg/kg respectively of the FCD anti-tb drug solution used for this study. After 21 days of administration of the drug solution at the specified dosage, blood sample was collected and the sample was analyzed to obtain some hematological parameters and the serum protein (this includes, total protein and serum albumin), then the serum globulin was calculated. The hematological parameters that were obtained include; RBC count, TWBC count, Hb estimation, PCV and then the hematological indices were calculated using formula given by Ochei & Kolhatkar, 2000. The result obtained from sample analysis was statistically analyzed by one-way ANOVA using SPSS v.20.0. The statistical result was insignificant (p > 0.05) in most of the variables investigated except for the following that were significant (p < 0.05): RBC count for groups 1 and 2 (p-value = 0.000 and 0.008 respectively), MHC of group 2 (p-values= 0.005), MCV of groups 1 and 2 (p-values= 0.001 and 0.008 respectively) and serum protein level of group 2 (p-value= 0.030).

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IJTSRD10691
Volume-2 | Issue-2, February 2018
1689-1712
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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