Bacterial and fungal skin infections pose a significant and increasing global burden, as evidenced by recent statistics and trends. Skin and Soft Tissue Infections (SSTIs) are notably prevalent, surpassing urinary tract infections and pneumonia combined in incidence. Factors contributing to the rise of SSTIs include an aging population, higher numbers of immunocompromised individuals, and the emergence of multi-resistant pathogens. In the United States, the economic impact of SSTIs, predominantly from hospitalizations, was estimated at $13.8 billion in 2012[1-2]. Fungal skin infections also present a substantial global health issue, ranking as the most prevalent skin disease globally in 2017. The burden varies regionally, with sub-Saharan Africa showing particularly high rates. For instance, Mali had the highest DALY rate for fungal skin diseases in 2017. These infections contribute significantly to the overall disease burden worldwide [3].Emerging challenges such as antimicrobial resistance further complicate treatment efforts across bacterial, fungal, and viral infections. This has spurred intensified efforts in antimicrobial discovery and production. Meanwhile, advancements in diagnostic technologies have enhanced the precision of identifying causative agents, potentially reducing the need for empirical treatments and improving patient outcomes.
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