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Acetazolamide Lozenges as the Promising Candidate for Prophylaxis of High Altitude Sickness

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Acetazolamide Lozenges as the Promising Candidate for Prophylaxis of High Altitude Sickness


Bhushan Suryakant Mali | Prashant B. Patil | Rushikesh S. Bachhav



Bhushan Suryakant Mali | Prashant B. Patil | Rushikesh S. Bachhav "Acetazolamide Lozenges as the Promising Candidate for Prophylaxis of High Altitude Sickness" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-1, December 2021, pp.1594-1605, URL: https://www.ijtsrd.com/papers/ijtsrd49085.pdf

The present study aimed to formulate and evaluate Acetazolamide as a lozenge to combat flaws in regard to conventional dosage form. Mountain sickness is a distressing disease common in the estimated hundred million who briskly ascend from lower altitudes to elevations above 2500 m. around the world. It is manifests with headache, which is often associated with fatigue, lightheadedness, anorexia, nausea, vomiting and disturbed sleep with frequent awakening. Acetazolamide is a carbonic anhydrase inhibitor works by shortening the period of high-altitude acclimatization; by inhibiting conversion of carbon dioxide to bicarbonate, the resultant metabolic acidosis may also increase oxygenation during hypoxia. Lozenges were manufactured by heating and congealing method with sucrose with dextrose as a base of lozenge and HPMC (E5) in varying concentrations. Preformulation illustrated compatibility of excipients and drugs coordinated using FT-IR. Post formulation parameters were studied. Formulation F2 was considered as excellent medicated confection that met all the requirements showing adequate hardness and disintegration of 10.3 kg/cm2 and 9.24 minutes respectively with a strong drug release rate of 99.14%. The acetazolamide lozenges can be a better approach for high altitude problems in prevention as well as treatment in emergency conditions with shorter half-life.

Acetazolamide; Acute mountain sickness; bioavailability; high altitude; Hypoxia; Lozenges; systemic absorption.


IJTSRD49085
Volume-6 | Issue-1, December 2021
1594-1605
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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