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Mystery of Uterine Leiomyosarcoma: Possible Reasons for the High Prevalence of Hematogenous Metastases

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Mystery of Uterine Leiomyosarcoma: Possible Reasons for the High Prevalence of Hematogenous Metastases


Takuma Hayashi | Kenji Sano | Ikuo Konishi



Takuma Hayashi | Kenji Sano | Ikuo Konishi "Mystery of Uterine Leiomyosarcoma: Possible Reasons for the High Prevalence of Hematogenous Metastases" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5, August 2020, pp.426-429, URL: https://www.ijtsrd.com/papers/ijtsrd31886.pdf

Uterine leiomyosarcoma is a refractory tumor that recurs and metastasizes repeatedly. The differential diagnosis between uterine leiomyoma (uterine fibroid) and uterine sarcoma that occurs in many adult women of all races is extremely difficult. In the current clinical management, treatment of uterine sarcoma is limited to surgical procedures. Therefore, it is desired to establish a molecular-targeted therapeutic method that has a life-prolonging effect. We reported that uterine sarcoma frequently occurs spontaneously in mice lacking the proteasome component low molecular protein 2/bl1 (LMP2/bl1). Therefore, we examined the expression status of LMP2/bl1 in biopsy tissues of various uterine mesenchymal tumors selected from pathological files by immunohistochemical staining. We reported that LMP2/bl1 expression was significantly attenuated in specifically uterine sarcoma. Malignant tumor stem cells have stronger antitumor drug resistance and radiation resistance than ordinary malignant tumor cells. Therefore, the presence of malignant tumor stem cells is considered to be a major cause of recurrence of malignant tumor cells after existing antitumor agents and radiotherapy. Currently, we have isolated stem-like cells from surgically excised human uterine sarcoma tissue, have been studying the biological characteristics of uterine sarcoma stem-like cells. From the results of our research to date, it was revealed that uterine sarcoma stem-like cells have a stronger hematogenous metastatic ability as compared with uterine sarcoma cells. The results of this research will provide useful medical information for the development of new treatments for uterine sarcoma with hematogenous metastatic potential.

Leiomyosarcoma, tumor stem cell, angiogenesis, hematogenous metastasis


IJTSRD31886
Volume-4 | Issue-5, August 2020
426-429
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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