The ethanolic leaf extract of Tecoma stans (L.) Juss. demonstrates potent therapeutic potential as both an antidiabetic and antioxidant agent, validated through various chemical and biological assays. Phytochemical analysis reveals a rich composition of bioactive compounds, specifically alkaloids like tecomine and various phenolic flavonoids, which drive its medicinal efficacy. Its antidiabetic action is characterized by the significant inhibition of carbohydrate-digesting enzymes, such as -amylase and-glucosidase, alongside an insulin-mimetic effect that effectively lowers blood glucose levels in streptozotocin-induced diabetic models. Simultaneously, the extract exhibits robust antioxidant properties by scavenging free radicals and reducing lipid peroxidation, thereby protecting cellular structures from the oxidative stress typically exacerbated by chronic hyperglycemia. These dual actions suggest that Tecoma stans not only helps manage glucose homeostasis but also mitigates the systemic secondary complications associated with diabetes.
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