Advanced maternal age is defined as age above 35 in females. Advanced maternal age is progressively recognized as a serious societal and clinical issue, as women are more choose to delay in pregnancy planning until their late 30s or early 40s. Advanced maternal age is linked with poor ovarian reserve and diminished oocyte quality, leading to complications in fertility. Numerous social factors like higher education, career accomplishments, and ineffective state support for families following this trend. The possibility of successful pregnancy highly depends on the age at which women starts her conception planning, with maternal age being a crucial factor in assisted reproductive technologies like IVF. Over time, the oocytes and embryos lose integrity of aging women that are related to energy production as well as cell cycle regulation which can result in a higher frequency for chromosomal aneuploidy. Most of these chromosomal abnormalities result from errors during oogenesis, especially in meiosis I. Moreover, the aging process also affects mitochondrial function and telomere integrity that are crucial for both oocyte quality and developmental competence as well. Healthcare Providers should proactively counsel women on their fertility preservation options, specifically oocyte vitrification as a counterbalance to age-related declines in reproductive potential. Not just for medical reasons like cancer treatment, but also your own personal family planning choices. In conclusion, the issue of fertility with AMA is a complex one and will require more than just measures to prolong the reproductive years.
Advanced maternal age, poor ovarian reserve, reproduction, oocyte quality, delayed fertility, chromosomal aneuploidy, telomere integrity, fertility preservation, assisted reproductive technologies
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