After 10 years of increasing conflict and violence in Syria, women face significant challenges associated with lack of adequate access to maternal health services, threatening their lives along with their immediate and long-term health outcomes, among them miscarriage, which has been increasing dramatically. Our aim was to assess whether serum total antioxidant (TAS) capacity and total oxidant status (TOS) altered during first trimester pregnancies with vaginal bleeding and abdominal pain, and to investigate the accuracy of these biomarkers in the prediction of miscarriage. In this cross-sectional study, A group of pregnant women with vaginal bleeding and abdominal pain (n=29) served as patient group and a control group of healthy pregnancies (n=30) were included. All of the participants in the two groups were matched for age and gestational age. All pregnant women were recruited from the Khaled Kendel hospital-Sarmada, Syria, and Blood samples were collected at 6–14 weeks from all participants for measurement of oxidative stress markers. The area under curve (AUC) was used to determine the predictive value of the oxidative stress indices. The mean TOS level was significantly (P<0.05) higher in patients whereas mean TAS level was significantly (P<0.05) decreased in patient group compared to the control group. The AUC of TOS and TAS were (0.611, 0.895, P= 0.115, 0.001) respectively. The cut-off, sensitivity, and specificity of TAS were (> 0.98, 93.5 and 70.8) respectively. TAS can be used to discriminate between TM and the control subjects (sensitivity= 0.956; P <0.0001). Our analysis of patients presenting with threatened miscarriage in this study presents, imbalance in oxidative stress markers, we recommended supplementing of anti-oxidants Throughout pregnancy. finally, Further high-quality research in this area is warranted to confirm our results.
Threatened miscarriage, oxidative stress indices, ROC curve, Syrian pregnant
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