Background: Hypothyroidism refers to the common pathological condition of thyroid hormone deficiency. It is the most common disorder after Diabetes Mellitus. The prevalence of hypothyroidism in India is 11% and 4-5% in worldwide. It is a hypometabolic clinical state resulting from inadequate secretion of thyroid hormones for prolonged periods or rarely from resistance of the peripheral tissues to the effects of thyroid hormones. Generally, hypothyroidism, a metabolic disorder can consider as agnimandya. All signs and symptoms of hypothyroidism are kaphapradhana. Kaphaja galaganda can be considered as hypothyroidism based on lakshnas and sthana. Kaphaketu rasa is one such yoga explained in Rasendra Chintamani containing Shuddha tankana, shankha bhasma, Shuddha vatsanabha and Shuddha pippali with three ardraka swarasa bhavana with indication in all kaphaja rogas like swasa kasa galarogas peenasa etc Objective- the aim of study was to evaluate anti-hypothyroid effect Of Kapha Ketu Rasa in PTU induced hypothyroid rat models. Materials & methods Hypothyroidism was induced by giving Propyl Thio Uracil to rats on daily basis. After one hour of giving inducing medicine, test drug is given for 30 days continuously. The effect of drug on body weight and thyroid hormones were quantified at 30th day. On 30th day animals were sacrificed and thyroid gland is dissected out and screened for histopathological study. Result & conclusion Experimental study Data showed decrease in TSH, and improvement in T3 and T4 hormone levels compared to diseased group. Histopathological values showed reduced congestion of blood vessels, reduction in follicular cell hyperplasia reduced inflammation, and no inflammatory infiltrate in test drug group.
Kaphaketu Rasa, shankha Bhasma, Hypothyroidism, kaphaja galaganda
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