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Evaluation of Antifungal Susceptibility Profile of Candida Species Isolated from Female Patients Attending Aminu Kano Teaching Hospital (AKTH)

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Evaluation of Antifungal Susceptibility Profile of Candida Species Isolated from Female Patients Attending Aminu Kano Teaching Hospital (AKTH)


Taura, D. W. | Yakubu, G. | Panda, T. W. | Dagona, A.G.

https://doi.org/10.31142/ijtsrd2395



Taura, D. W. | Yakubu, G. | Panda, T. W. | Dagona, A.G. "Evaluation of Antifungal Susceptibility Profile of Candida Species Isolated from Female Patients Attending Aminu Kano Teaching Hospital (AKTH)" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-5, August 2017, pp.976-985, URL: https://www.ijtsrd.com/papers/ijtsrd2395.pdf

The increasing incidence of Candidiasis affecting the genitourinary tracts as well as the introduction of new antifungal drugs has recently encouraged the need for performing fungal susceptibility tests. The study was aimed at evaluating the antifungal susceptibility profile of Candida species isolated from female patients attending Aminu Kano Teaching Hospital (AKTH), with suspected Candidal infections between August, 2012 to June, 2013. Five hundred and twenty one (521) clinical samples comprising 342 urine and 179 high vaginal swabs were cultured on Sabouraud dextrose agar. The Candida species isolated were identified to species level using Chromogenic agar and API 20 C AUX test kit. Antifungal susceptibility tests were performed using commercially prepared single antifungal disc (Bioanalyse Turkey). Out of these 521 samples analyzed only 59 yielded Candida species giving the overall prevalence of 11.3% with Candida albicans 22 (37.3%) as the common species isolated followed by C. glabrata 19 (32.2%), C. tropicalis 5(8.5%), C. krusei 3 (5.1%), C. magnoliae 3 (5.1%), C. lusitaniae 2 (3.4%), C. parapsilosis 2 (3.4%), C. famata 2 (3.4%) and C. guilliermondii 1 (1.7%). The antifungal susceptibility test shows that 81.4% of the isolates were susceptible to ketoconazole and only 3.4% to nystatin. However, 33.9% were susceptible, 13.6% intermediate susceptible and 52.5% resistant to fluconazole. Similarly 28.8% were susceptible, 5.1% intermediate susceptible and 66.1% resistant to voriconazole. Additionally 25.4% were susceptible, 11.9% intermediate susceptible and 62.7% resistant to flucytosine. All the C. krusei isolates were completely resistant to azole drugs while C. famata were resistant to all the drugs tested. Two quality control strains of Candida namely: Candida tropicalis ATCC 750 and Candida albicans ATCC 90028 were used.

Evaluation, Antifungal susceptibility Profile, Candida species


IJTSRD2395
Volume-1 | Issue-5, August 2017
976-985
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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