CRP plays important roles in inflammatory processes and host responses to infection including the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of cytokines, particularly interleukin-6 and tumor necrosis factora. Early work on CRP can seem somewhat unclear and at times conflicting since it was often not specified which particular CRP isoform was measured or utilized in experiments and whether responses attributed to nCRP were in fact possibly due to dissociation into mCRP or lipopolysaccharide contamination. Each CRP isoform plays at sites of local inflammation and infection. CRP production is part of the nonspecific acute-phase response to most forms of inflammation, infection, and tissue damage.
CRP, inflammation, interleukin
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