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Formulation and Evaluation of Gliclazide Immediate Release and Metformin Sustain Release Bilayer Tablet

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Last date : 27-Aug-2022

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Formulation and Evaluation of Gliclazide Immediate Release and Metformin Sustain Release Bilayer Tablet


Gajanan Ramasane | Sujit Kakade | Ashok Bhosale



Gajanan Ramasane | Sujit Kakade | Ashok Bhosale "Formulation and Evaluation of Gliclazide Immediate Release and Metformin Sustain Release Bilayer Tablet" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5, August 2022, pp.19-31, URL: https://www.ijtsrd.com/papers/ijtsrd50372.pdf

The aim of the present work is to formulate and evaluate a bilayer tablet (BT) of Metformin HCl as Sustained release and Gliclazide as Immediate release (IR). The polymer used in sustained release is HMPC K100M and the super disintegrant used in immediate release in proportion of Gum Karaya & Croscarmellose sodium by Direct compression method. The Preformulation studied, Bulk density, Tapped density, Housner’s ratio, Carr’s index, Angle of repose and UV of Metformin HCl and Gliclazide is performed. In this study, a bilayer tablet containing gliclazide in IRL and metformin in SRL was made using the direct compression method, with the goal of making the formulations IRL as small as possible. Will release gliclazide as soon as possible to combat postprandial hyperglycaemic level, followed by steady-state plasma glucose management by Metformin with a long-term release. The hardness of the different formulations ranged from 7.5-8.5 kg/cm. All the formulations exhibited less than 1% friability. The drug content analysis of Metformin and Gliclazide in all formulations was found within the I P limits (±5%) which indicate that the drug was uniformly distributed in the tablets. The in-vitro dissolution study was performed for layer I (Metformin) up to 12 hrs (after every 1hour intervals) and for layer II (Gliclazide) up to 40 min (after every 5 min interval). The bilayer tablet contributing initial loading dose and dissolves rapidly, the remainder of the drug in the extended release was constant rate till the end of the dissolution process. The DSC & I.R spectra proved that there was no interaction between the polymer/ excipients and Metformin, Gliclazide. The stability study of Formulation F4 showed after three months that there was no degradation and the drug was stable under accelerated and real time stability conditions.

Bilayer tablet, Immediate release layer, Sustain release layer


IJTSRD50372
Volume-6 | Issue-5, August 2022
19-31
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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