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Preliminary Study of Phytochemical Constituents and Acute Toxicity of Hibiscus Sabdariffa Extracts

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Preliminary Study of Phytochemical Constituents and Acute Toxicity of Hibiscus Sabdariffa Extracts


Dada, I. B. O. | Bada, S. O.



Dada, I. B. O. | Bada, S. O. "Preliminary Study of Phytochemical Constituents and Acute Toxicity of Hibiscus Sabdariffa Extracts" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6, October 2019, pp.997-1001, URL: https://www.ijtsrd.com/papers/ijtsrd29288.pdf

This study was done to assess the phytochemical constituents and acute toxicity of Hibiscus sabdariffa calyx and leaf extract. The crude extract of the plant parts were obtained after solvent percolation and drying. Then, the presence of tannins, saponin, flavonoids, alkaloids and phenol were assessed qualitatively. Also, albino rats (Rattus norvegicus) were used to assess the toxicity level of the plant materials, haematological and biochemical parameters of the test animal blood were also assessed. The results revealed that the two plant parts contained alkaloids, tannins, saponin, phenol and flavonoids. Also, In the acute toxicity assay, the oral lethal dose (LD50) of ?5000 mg/kg bw and 2236.07 mg/kg bw were recorded respectively for the calyx and leaf extract of the plant. The plant calyx and leaf extracts showed no significant (p<0.05) effect on the levels of red blood cells (RBC), white blood cells (WBC), packed cell volume (PCV), and haemoglobin concentration (Hb) albeit, the plant extracts had a significant increase effect on the platelet count of the rats. there was a significant increase in the alkaline phosphatase (ALP), Alanine amino transaminase (ALT) and Aspartate amino transaminase (AST) in the group treated with the leaf extract compared with the control whereas the group treated with the calyx extract had comparable level of these enzymes with that of the control. These results has lent credence to the medicinal claim of the plant parts however, the leaf of the plant should be used in moderation.

Hibiscus sabdariffa, phtochemica, acute toxicity, haematology, biochemical


IJTSRD29288
Volume-3 | Issue-6, October 2019
997-1001
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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