Cefotaxime is a synthetic ??-lactam antibiotic that is active against Gram-negative and Gram-positive bacteria. Cefotaxime is able to chelate metal ions due to the presence of C=O, NH2, COOH, COOR, NH and NO electron donating groups. The stability constants and Gibbs free energies of cefotaxime-Zn(II) were determined colorimetrically at 25 and 40 oC using continuous variation and mole ratio methods. The formation of Zn(II) complex with cefotaxime was studied colorimetrically at an absorption maximum of 430 nm at different temperatures. The data showed that Zn(II) and cefotaxime combine in the molar ratio of 1:2 at pH 7.4 with ionic strength maintained using 0.1M KNO3. Calculated stability constants values were 1.96 x 105 and 1.28 x 105 using continuous variation method and 1.11 x 105 and 1.11 x 105 using mole ratio methods at 25 and 40 oC respectively. Calculated ?GO for the complex were -3.01 x 104 and -3.06 x 104 J using continuous variation method and -2.88 x 104 J and -3.02 x 104 J using mole ratio method at 25 and 40 oC respectively. The stability constant results suggested that cefotaxime used in the study is a good chelating agent and can be an efficient antidote in the therapy of Zn(II) overload or poisoning.
Cefotaxime, zinc, complex, stability constant, Gibbs free energy
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