Diabetes mellitus is a prevalent metabolic disorder characterized by chronic hyperglycemia and disturbances in carbohydrate, protein, and lipid metabolism. The search for effective natural remedies to manage diabetes has garnered significant attention in recent years. This study evaluates the hypoglycemic and hypolipidemic potential of an aqueous extract of Cinnamomum zeylanicum (CZ) in alloxan-induced diabetic mice (Mus musculus). Adult male Swiss albino mice were divided into control, diabetic, and CZ-treated diabetic groups. Diabetes was induced using alloxan monohydrate (60 mg/kg body weight), and the CZ extract was administered orally at a dose of 150 mg/kg body weight for 28 days. Biochemical parameters, including serum protein, total cholesterol, and blood glucose levels, were measured at regular intervals. Results demonstrated a significant reduction in blood glucose and total cholesterol levels in CZ-treated diabetic mice compared to untreated diabetic mice, indicating its antihyperglycemic and hypolipidemic effects. Additionally, serum protein levels were restored toward normal in the CZ-treated group, suggesting a protective effect against protein degradation. The bioactive compounds in CZ, such as cinnamaldehyde and polyphenols, are believed to play a key role in these therapeutic effects. The findings highlight the potential of Cinnamomum zeylanicum as a natural adjunct in diabetes management, warranting further studies to elucidate its mechanisms of action and optimize its clinical application.
Mice, Protein, Cholesterol, Cinnamomum zeylanicum, Blood Glucose
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