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Role of Oxidative Stress in Assessment of Damage Induced by Lead Acetate in Mice Gastrocnemius Muscle

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Role of Oxidative Stress in Assessment of Damage Induced by Lead Acetate in Mice Gastrocnemius Muscle


Sushma Sharma | Anita Thakur


https://doi.org/10.31142/ijtsrd18927


Sushma Sharma | Anita Thakur "Role of Oxidative Stress in Assessment of Damage Induced by Lead Acetate in Mice Gastrocnemius Muscle" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-1, December 2018, pp.47-50, URL: https://www.ijtsrd.com/papers/ijtsrd18927.pdf

Heavy metal deposition has increased due to the anthropogenic activities leading to heavily polluted areas worldwide. The objective of present study was to evaluate the effect of lead acetate [Pb(C2H3O2)2] on antioxidant enzyme activities in gastrocnemius muscle of mice. Lead is a toxic heavy metal widely distributed in the environment due to its role in modern industry. Normal healthy looking mice showing no sign of morbidity were divided into three groups. Group I was designated as control whereas group II and group III received lead acetate having doses 10 mg/kg body weight of lead acetate, daily and 150 mg/kg body weight of lead acetate, weekly respectively. Study was performed at 40 and 80 days stages. Lead acetate significantly decreases antioxidant enzymes and increase oxidative stress along with muscle tissue damage.

Lead acetate, gastrocnemius muscle, Antioxidant enzymes


IJTSRD18927
Volume-3 | Issue-1, December 2018
47-50
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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