Sulphate occurs naturally in the environment as a component of the sulphur cycle, involving both atmospheric and terrestrial processes. Sulphur compounds are widely distributed in the natural environment, with sulphate and sulphite being the predominant forms. The present investigation was carried out to examine the effects of sodium sulfate solution in albino mice and to evaluate the protective role of Azadirachta indica leaf extract. A total of 24 albino mice (Mus musculus) were used and equally divided into three groups: one control group and two experimental groups. The control group was maintained on a standard diet with distilled water. The first experimental group (n = 8) was orally administered 1% sodium sulfate solution (0.5 ml per mouse per day) for 28 days. The second experimental group (n = 8) received both 1% sodium sulfate solution and a freshly prepared 2% aqueous extract of Azadirachta indica (0.5 ml per mouse per day) for the same duration of 28 days, while being maintained on a normal diet with distilled water similar to the control group. After 28 days of treatment, biochemical parameters such as blood glucose, serum cholesterol, and plasma protein were measured in all three groups (control and experimental). A significant reduction in these parameters was observed in the second group of mice treated only with sodium sulfate. However, mice in the third group, which received both sodium sulfate and the aqueous leaf extract of Azadirachta indica, showed a noticeable improvement. These results suggest that the aqueous leaf extract of A. indica has a beneficial effect in mitigating the adverse changes induced in mice.
Sodium sulfate, Azadirachta indica, Amelioration, Albino mice, Biochemical parameters.
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