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Methanol Extract of Unfermented Theobroma Cacao Promotes Normal Lipid Profile of Wistar Rats

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Methanol Extract of Unfermented Theobroma Cacao Promotes Normal Lipid Profile of Wistar Rats


Eyuwa Ignatius Agwupuye | Justin Atiang Beshel | Assumpta Chioma Anosike | Lawrence U. Ezeanyika

https://doi.org/10.31142/ijtsrd21730



Eyuwa Ignatius Agwupuye | Justin Atiang Beshel | Assumpta Chioma Anosike | Lawrence U. Ezeanyika "Methanol Extract of Unfermented Theobroma Cacao Promotes Normal Lipid Profile of Wistar Rats" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-3, April 2019, pp.190-193, URL: https://www.ijtsrd.com/papers/ijtsrd21730.pdf

Abnormal lipid metabolism is a major pathogenic factor for various cardiovascular diseases. The present study investigated the lipid profile of methanol extract of unfermented Theobroma cacao (TC) in Wistar rats. 24 Male Wistar rats were divided equally into four groups. Group 1 was the control group, and was administered 0.9% normal saline. Groups 2, 3 and 4 were administered 200mg/kg, 400mg/kg and 800mg/kg methanol extract of unfermented TC. Administration was via oral gavage and lasted for 21 days. The rats were sacrificed under chloroform anaesthesia. Blood was collected through cardiac puncture, allowed to clot, and later centrifuged to get serum. Laboratory assays were done for serum concentrations of total cholesterol (Tc), triacylglycerides (TAG), high density lipoprotein (HDL-c), and low density lipoprotein (LDL-c). Administration of TC extract resulted in an increase (p<0.05) serum concentration of HDL-c, with a consequent reduction in the serum concentrations of Tc, TAG, and LDL-c when compared with the control. The observed results showed that consumption of unfermented Theobroma cacao within the experimental dose promotes normal lipid profile of Wistar rats. Thus, if these results are extrapolated to man, consumption of unfermented Theobroma cacao is encouraged.

Theobroma Cacao, Total cholesterol, Triacylglycerides, High Density Lipoprotein


IJTSRD21730
Volume-3 | Issue-3, April 2019
190-193
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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