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Advances and Problems in Preclinical Models for Childhood Cancer

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Advances and Problems in Preclinical Models for Childhood Cancer

V. Sah

V. Sah "Advances and Problems in Preclinical Models for Childhood Cancer" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4, June 2021, pp.762-765, URL: https://www.ijtsrd.com/papers/ijtsrd42379.pdf

Microblogging today has gotten an acclaimed specific instrument among Neuroblastoma is a sympathetic nervous system disease in children and is the most prevalent solid tumor in childhood, accounting for 15% of all pediatric oncology deaths. Nearly 80% of patients with this clinically active condition do not react to current treatments in the long run. The precise portrayal of tumor biology and diversity is the key obstacle in the discovery and evaluation of novel agents for pediatric drug growth. In addition to this restriction, the low prevalence of neuroblastoma renders it difficult to enroll qualifying patients for early phase clinical trials, emphasizing the importance of thorough preclinical studies to ensure that the right drugs are chosen. To address these issues, researchers need new preclinical models, technologies, and principles. Tissue engineering provides appealing methods for developing three-dimensional (3D) cell models utilizing different biomaterials and manufacturing techniques that replicate the geometry, dynamics, heterogeneity, metabolic gradients, and cell connectivity of the native tumor microenvironment. We address existing laboratory models and evaluate their ability to reflect the systemic organization and physiological conditions of the human body, as well as current and emerging strategies to recapitulate the tumor niche utilizing tissue-engineered platforms in this study. Finally, we'll talk about how innovative 3Din vitroculture systems might be used to answer unanswered questions in neuroblastoma biology.

Neuroblastoma, Tissue-engineering, childhood cancer

Volume-5 | Issue-4, June 2021
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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