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Prevalence of Gene Polymorphisms in Intervertebral Disc Degenerative Diseases

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Prevalence of Gene Polymorphisms in Intervertebral Disc Degenerative Diseases


Mr. C. Marimuthu | Dr. V. Pushpa Rani | Dr. V. Judia Harriet Sumathy

https://doi.org/10.31142/ijtsrd19153



Mr. C. Marimuthu | Dr. V. Pushpa Rani | Dr. V. Judia Harriet Sumathy "Prevalence of Gene Polymorphisms in Intervertebral Disc Degenerative Diseases" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-2, February 2019, pp.292-298, URL: https://www.ijtsrd.com/papers/ijtsrd19153.pdf

Intervertebral disc diseases is otherwise known as breakdown of one or more discs that separate the bone of the spine, Which cause pain in the back, neck as well as frequent pain in legs and arms. The general role of intervertebral discs is to provide the cushioning between vertebrae and absorb the pressure that is exerted on the spine. Generally low back pain(LBP) is considered as common disorder from disc degenerative diseases. The main reason of the LBP is due to contribution of intervertebral disc diseases and combination of genetic and environmental factors. Most of these factor identified , But some of these remain unidentified. However recent researches identified that variations in several genes may influence the risc of intervertebral disc diseases . Most of the variations associated with genes related with immune function leads to increase risk of intervertebral disc diseases . Most of these genes plays a vital role in immune response like inflammation and water loss (dehydration) of the discs, Which causes their degeneration. This review focuses on the evidence of genetic disposition, the genes or biological processes that are implicated, and the need to consolidate resources and clarify phenotype definition to take advantage of the new technologies in genetic analysis to enhance our understanding of this condition.

Genetic factor, Intervertebral disc degeneration , Degenerative disc disease , intervertebral disc degeneration, low back pain, nucleus pulposus, annulus fibrosus, endplate, extracellular matrix, Polymorphism


IJTSRD19153
Volume-3 | Issue-2, February 2019
292-298
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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