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Lymphocytopenia and COVID19: A Literature Review

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Lymphocytopenia and COVID19: A Literature Review

Shatabdi Dey | P. K Sahoo

Shatabdi Dey | P. K Sahoo "Lymphocytopenia and COVID19: A Literature Review" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2, February 2021, pp.213-217, URL: https://www.ijtsrd.com/papers/ijtsrd38373.pdf

The novel coronavirus SAR-CoV-2 has resulted in huge wave of worldwide fear by its contagious nature, virulence and high mortality. Persistence condition of the disease with T-cells and Natural killer cells exhaustion leads to Lymphopenia or Lymphocytopenia. Lymphocytopenia is a condition of low lymphocyte count in the blood. Lymphocytopenia is an important adverse effect of COVID-19 as well as negative prognostic marker in many malignancies. It leads to hyper activation of immune system that can cause immunosuppression and promote cytokine storm that eventually leads to multi-organ failure and death. Restoration of lymphocytes and its function would be helpful to boost the immune response against COVID-19 disease. This review analyses the possible causes that may lead to the lymphocyte reduction in COVID-19 patients, and highlighting the possible therapeutic strategies that will help to control and prevent lymphocytopenia in COVID-19 patients.

COVID-19, SAR-CoV-2, T-lymphocytes, NK cells, Lymphocytopenia, cytokine storm

Volume-5 | Issue-2, February 2021
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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