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Sperm Motility as a Screening Strategy for the Identification of Microtubule Targeting Drugs

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Sperm Motility as a Screening Strategy for the Identification of Microtubule Targeting Drugs


Aijaz Rashid

https://doi.org/10.31142/ijtsrd2209



Aijaz Rashid "Sperm Motility as a Screening Strategy for the Identification of Microtubule Targeting Drugs" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-4, June 2017, pp.723-727, URL: https://www.ijtsrd.com/papers/ijtsrd2209.pdf

Microtubule targeting drugs are considered as successful anticancer agents. The hunt for novel microtubules targeting agents is an exciting anticancer research area, as new drugs, may not only show better potency and bioavailability but may also differentially affect the microtubule assembly and thus provide new insights about microtubule dynamics and polymer biology. Cold liable nature of microtubules is bases for tubulin isolation and screening of novel tubulin binding agents. Direct effect of different compounds on microtubule architecture and mitotic index in MCF-7/HeLa cell cultures is also used as a screening strategy. SRB/MTT assays that measure cell proliferation are also used as preliminary screening strategy to determine the effect of different compounds on cell proliferation for identifying microtubule targeting agents. Keeping in view the complexity of these assay systems, the possibility of sperm motility as a screening strategy for identifying the novel microtubule targeting drugs/agents was explored. So, the effect of known microtubule targeting agents on sperm motility was determined. The results suggest that nocodazole and colchicine does not affect sperm motility, thusimpairment in sperm motility cannot be developed as a general method for screening of microtubule targeting drugs. However, curcumin was identified as a potent compound affecting sperm motility, indicating the possibility that in future curcumin or its derivatives might be used as natural contraceptives.

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IJTSRD2209
Volume-1 | Issue-4, June 2017
723-727
IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470
Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

International Journal of Trend in Scientific Research and Development - IJTSRD having online ISSN 2456-6470. IJTSRD is a leading Open Access, Peer-Reviewed International Journal which provides rapid publication of your research articles and aims to promote the theory and practice along with knowledge sharing between researchers, developers, engineers, students, and practitioners working in and around the world in many areas like Sciences, Technology, Innovation, Engineering, Agriculture, Management and many more and it is recommended by all Universities, review articles and short communications in all subjects. IJTSRD running an International Journal who are proving quality publication of peer reviewed and refereed international journals from diverse fields that emphasizes new research, development and their applications. IJTSRD provides an online access to exchange your research work, technical notes & surveying results among professionals throughout the world in e-journals. IJTSRD is a fastest growing and dynamic professional organization. The aim of this organization is to provide access not only to world class research resources, but through its professionals aim to bring in a significant transformation in the real of open access journals and online publishing.

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